Protocol for predicting suppressors of celldeath pathways based on transcriptomic and vulnerability data
Targeted gene therapy shuts down cancer cells’ energy centers >>
PNKP targeting engages the autophagic machinery through STING and STAT3 to potentiate ferroptosis and chemotherapy in TNBC
Targeted gene therapy shuts down cancer cells’ energy centers >>
Pictures of Students in Prof. Sima Lev’s Lab
This gallery presents the students of Professor Sima Lev’s lab in Weizmann Institute of Science:
Cell Signaling in Cancer Biology
Several key signaling pathways control the growth and motility of normal cells, whereas abnormal activation of these pathways often leads to uncontrolled cell growth and motility, cell transformation and cancer development. Over the last few decades a remarkable progress in the signal transduction field led to identification of signaling pathways and key genes known as […]
Signaling by PYK2 and FAK
PYK2 and its closely related focal adhesion kinase (FAK) are key mediators of various mitogenic and migratory pathways. Prof. Sima Lev discovered PYK2 and showed that it is tightly regulated by intracellular calcium level and mediates mitogenic signals of diverse growth factors, hormones and neuropeptides. PYK2 is also activated by integrin clustering, localizes to focal […]