Signaling by PYK2 and FAK
PYK2 and its closely related focal adhesion kinase (FAK) are key mediators of various mitogenic and migratory pathways. Prof. Sima Lev discovered PYK2 and showed that it is tightly regulated by intracellular calcium level and mediates mitogenic signals of diverse growth factors, hormones and neuropeptides. PYK2 is also activated by integrin clustering, localizes to focal […]