Related Issues

Excellent lectures of Cell signaling in cancer biology, cover multiple central topics in cancer biology. Highly recommended by Prof. Sima Lev to every student postdoc and cancer scientist.

Sima Lev wrote: In recent years a breakthrough in cancer treatment strategies has been made by powerful approaches applying cancer immunotherapy, including cancer vaccines, adoptive cancer therapy and the immune checkpoint therapy. In particular, inhibition the immune checkpoint molecules, cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed cell death protein 1 (PD-1) which negative regulate T cell activation became a very powerful strategy for a wide range of human cancer including melanoma. James P Allison from The University of Texas MD Anderson Cancer Center and Tasuku Honjo of Kyoto University in Japan were awarded the 2018 Nobel Prize in Physiology or Medicine for the development immune checkpoint inhibitors to treat cancer. 

 Below a few videos related to cancer immunotherapy:

James P. Allison Nobel Lecture 

Cancer therapy by inhibition of negative immune regulation

Immune Checkpoint Therapy

Targeting Cancer Pathways: Understanding Immune Checkpoints

Part 1 

Part 2

Immunotherapy and CAR-T Cells

Advances and Challenges for Understanding Macrophages in the Tumor Microenvironment